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Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel

Numerous physiological functions rely on distinguishing temperature by temperature-sensitive transient receptor potential channels (thermo-TRPs). While thermo-TRP function has been studied extensively, structural determination of their heat- and cold-activated states has remained a challenge. Here,...

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Библиографические подробности
Опубликовано в: :Nat Struct Mol Biol
Главные авторы: Nadezhdin, Kirill D., Neuberger, Arthur, Trofimov, Yuri A., Krylov, Nikolay A., Sinica, Viktor, Kupko, Nikita, Vlachova, Viktorie, Zakharian, Eleonora, Efremov, Roman G., Sobolevsky, Alexander I.
Формат: Artigo
Язык:Inglês
Опубликовано: 2021
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8283911/
https://ncbi.nlm.nih.gov/pubmed/34239124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-021-00615-4
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