Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity

Atypical cadherin Celsr3 is critical for brain embryonic development, and its role in the postnatal cerebellum remains unknown. Using Celsr3-GFP mice, Celsr3 shows high expression in postnatal Purkinje cells (PCs). Mice with conditional knockout (cKO) of Celsr3 in postnatal PCs exhibit deficit in mo...

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Udgivet i:iScience
Main Authors: Zhou, Qinji, Qin, Jingwen, Liang, Yaying, Zhang, Wei, He, Siyuan, Tissir, Fadel, Qu, Yibo, Zhou, Libing
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8283331/
https://ncbi.nlm.nih.gov/pubmed/34308297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102812
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