Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

Epstein-Barr virus (EBV) encodes a G protein-coupled receptor (GPCR) termed BILF1 that is essential for EBV-mediated immunosuppression and oncogenesis. BILF1 couples with inhibitory G protein (Gi), the major intracellular signaling effector for human chemokine receptors, and exhibits constitutive si...

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Publicado no:Immunity
Main Authors: Tsutsumi, Naotaka, Qu, Qianhui, Mavri, Maša, Baggesen, Maibritt S., Maeda, Shoji, Waghray, Deepa, Berg, Christian, Kobilka, Brian K., Rosenkilde, Mette M., Skiniotis, Georgios, Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282746/
https://ncbi.nlm.nih.gov/pubmed/34216564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.06.001
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