A novel perioperative multi-dose methadone-based multi-modal analgesic strategy in children achieved safe and low analgesic blood methadone levels enabling opioid sparing sustained analgesia with minimal adverse effects

BACKGROUND: Intraoperative methadone, a long-acting opioid, is increasingly used for postoperative analgesia, although the optimal methadone dosing strategy in children is still unknown. Use of a single large dose of intraoperative methadone is controversial due to inconsistent reductions in total o...

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Detaylı Bibliyografya
Yayımlandı:Anesth Analg
Asıl Yazarlar: Sadhasivam, Senthilkumar, Aruldhas, Blessed W., Packiasabapathy, Senthil, Overholser, Brian R., Zhang, Pengyue, Zang, Yong, Renschler, Janelle S., Fitzgerald, Ryan E., Quinney, Sara K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282724/
https://ncbi.nlm.nih.gov/pubmed/33481403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000005366
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