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A novel perioperative multi-dose methadone-based multi-modal analgesic strategy in children achieved safe and low analgesic blood methadone levels enabling opioid sparing sustained analgesia with minimal adverse effects
BACKGROUND: Intraoperative methadone, a long-acting opioid, is increasingly used for postoperative analgesia, although the optimal methadone dosing strategy in children is still unknown. Use of a single large dose of intraoperative methadone is controversial due to inconsistent reductions in total o...
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| Опубликовано в: : | Anesth Analg |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8282724/ https://ncbi.nlm.nih.gov/pubmed/33481403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000005366 |
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