Circulating tumor cell chromosomal instability and neuroendocrine phenotype by immunomorphology and poor outcomes in men with mCRPC treated with abiraterone or enzalutamide

BACKGROUND: While the detection of the AR-V7 in CTCs is associated with resistance to abiraterone or enzalutamide (abi/enza) in men with metastatic castration resistant prostate cancer (mCRPC), it only accounts for a minority of this resistance. Neuroendocrine (NE) differentiation or chromosomal ins...

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Publicado no:Clin Cancer Res
Main Authors: Brown, Landon C., Halabi, Susan, Schonhoft, Joseph D., Yang, Qian, Luo, Jun, Nanus, David M., Giannakakou, Paraskevi, Szmulewitz, Russell Z., Danila, Daniel C., Barnett, Ethan S., Carbone, Emily A., Zhao, Jimmy L., Healy, Patrick, Anand, Monika, Gill, Audrey, Jendrisak, Adam, Berry, William R., Gupta, Santosh, Gregory, Simon G., Wenstrup, Richard, Antonarakis, Emmanuel S., George, Daniel J, Scher, Howard I., Armstrong, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282682/
https://ncbi.nlm.nih.gov/pubmed/33820782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3471
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