Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial

BACKGROUND: We evaluated the efficacy, pharmacokinetics (PK), and safety of clofazimine (CFZ) in patients living with human immunodeficiency virus (HIV) with cryptosporidiosis. METHODS: We performed a randomized, double-blind, placebo-controlled study. Primary outcomes in part A were reduction in Cr...

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Vydáno v:Clin Infect Dis
Hlavní autoři: Iroh Tam, Py, Arnold, S L M, Barrett, L K, Chen, C R, Conrad, T M, Douglas, E, Gordon, M A, Hebert, D, Henrion, M, Hermann, D, Hollingsworth, B, Houpt, E, Jere, K C, Lindblad, R, Love, M S, Makhaza, L, McNamara, C W, Nedi, W, Nyirenda, J, Operario, D J, Phulusa, J, Quinnan, G V, Sawyer, L A, Thole, H, Toto, N, Winter, A, Van Voorhis, W C
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282326/
https://ncbi.nlm.nih.gov/pubmed/32277809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciaa421
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