Robust Angiogenesis and Arteriogenesis in the Skin of Diabetic Mice by Transient Delivery of Engineered VEGF and PDGF-BB Proteins in Fibrin Hydrogels

Non-healing ulcers are a serious complication of diabetes mellitus and a major unmet medical need. A major cause for the lack of healing is the impairment of spontaneous vascularization in the skin, despite mostly normal blood flow in deeper large vessels. Therefore, pro-angiogenic treatments are ne...

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Bibliografiske detaljer
Udgivet i:Front Bioeng Biotechnol
Main Authors: Certelli, Alessandro, Valente, Paolo, Uccelli, Andrea, Grosso, Andrea, Di Maggio, Nunzia, D’Amico, Rosalinda, Briquez, Priscilla S., Hubbell, Jeffrey A., Wolff, Thomas, Gürke, Lorenz, Mujagic, Edin, Gianni-Barrera, Roberto, Banfi, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Bioengineering and Biotechnology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8281302/
https://ncbi.nlm.nih.gov/pubmed/34277588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2021.688467
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