TLR4-Endothelin Axis Controls Syncytiotrophoblast Motility and Confers Fetal Protection in Placental Malaria

Pregnancy-associated malaria is often associated with adverse pregnancy outcomes. Placental circulatory impairments are an intriguing and unsolved component of malaria pathophysiology. Here, we uncovered a Toll-like receptor 4 (TLR4)-TRIF-endothelin axis that controls trophoblast motility and is lin...

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Udgivet i:Infect Immun
Main Authors: Pandya, Yash, Marta, Alexander, Barateiro, André, Bandeira, Carla Letícia, Dombrowski, Jamille Gregório, Costa, João, Marinho, Cláudio Romero Farias, Penha-Gonçalves, Carlos
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8281214/
https://ncbi.nlm.nih.gov/pubmed/34061587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00809-20
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