HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth

A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize a widely mutated viral envelope protein. No vaccine has yet...

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Udgivet i:Sci Rep
Main Authors: Fries, Chelsea N., Chen, Jui-Lin, Dennis, Maria L., Votaw, Nicole L., Eudailey, Joshua, Watts, Brian E., Hainline, Kelly M., Cain, Derek W., Barfield, Richard, Chan, Cliburn, Moody, M. Anthony, Haynes, Barton F., Saunders, Kevin O., Permar, Sallie R., Fouda, Genevieve G., Collier, Joel H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8280189/
https://ncbi.nlm.nih.gov/pubmed/34262096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93702-x
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