Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

Caveolae-associated protein 3 (cavin3) is inactivated in most cancers. We characterized how cavin3 affects the cellular proteome using genome-edited cells together with label-free quantitative proteomics. These studies revealed a prominent role for cavin3 in DNA repair, with BRCA1 and BRCA1 A-comple...

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Veröffentlicht in:eLife
Hauptverfasser: McMahon, Kerrie-Ann, Stroud, David A, Gambin, Yann, Tillu, Vikas, Bastiani, Michele, Sierecki, Emma, Polinkovsky, Mark E, Hall, Thomas E, Gomez, Guillermo A, Wu, Yeping, Parat, Marie-Odile, Martel, Nick, Lo, Harriet P, Khanna, Kum Kum, Alexandrov, Kirill, Daly, Roger, Yap, Alpha, Ryan, Michael T, Parton, Robert G
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2021
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279762/
https://ncbi.nlm.nih.gov/pubmed/34142659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61407
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