Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19

A recent report found that rare predicted loss-of-function (pLOF) variants across 13 candidate genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe COVID-19 cases. We performed whole-exome or whole-genome sequencing of 1,864 COVID-19 cases (713 with severe and 1,151 wit...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Povysil, Gundula, Butler-Laporte, Guillaume, Shang, Ning, Wang, Chen, Khan, Atlas, Alaamery, Manal, Nakanishi, Tomoko, Zhou, Sirui, Forgetta, Vincenzo, Eveleigh, Robert J.M., Bourgey, Mathieu, Aziz, Naveed, Jones, Steven J.M., Knoppers, Bartha, Scherer, Stephen W., Strug, Lisa J., Lepage, Pierre, Ragoussis, Jiannis, Bourque, Guillaume, Alghamdi, Jahad, Aljawini, Nora, Albes, Nour, Al-Afghani, Hani M., Alghamdi, Bader, Almutairi, Mansour S., Mahmoud, Ebrahim Sabri, Abu-Safieh, Leen, El Bardisy, Hadeel, Harthi, Fawz S. Al, Alshareef, Abdulraheem, Suliman, Bandar Ali, Alqahtani, Saleh A., Almalik, Abdulaziz, Alrashed, May M., Massadeh, Salam, Mooser, Vincent, Lathrop, Mark, Fawzy, Mohamed, Arabi, Yaseen M., Mbarek, Hamdi, Saad, Chadi, Al-Muftah, Wadha, Jung, Junghyun, Mangul, Serghei, Badji, Radja, Thani, Asma Al, Ismail, Said I., Gharavi, Ali G., Abedalthagafi, Malak S., Richards, J. Brent, Goldstein, David B., Kiryluk, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279578/
https://ncbi.nlm.nih.gov/pubmed/34043590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI147834
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