Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia

Activation of the hypoxia-inducible factor (HIF) pathway reprograms energy metabolism. Hemoglobin (Hb) is the main carrier of oxygen. Using its normal variation as a surrogate measure for hypoxia, we explored whether lower Hb levels could lead to healthier metabolic profiles in mice and humans (n =...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Auvinen, Juha, Tapio, Joona, Karhunen, Ville, Kettunen, Johannes, Serpi, Raisa, Dimova, Elitsa Y., Gill, Dipender, Soininen, Pasi, Tammelin, Tuija, Mykkänen, Juha, Puukka, Katri, Kähönen, Mika, Raitoharju, Emma, Lehtimäki, Terho, Ala-Korpela, Mika, Raitakari, Olli T., Keinänen-Kiukaanniemi, Sirkka, Järvelin, Marjo-Riitta, Koivunen, Peppi
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279517/
https://ncbi.nlm.nih.gov/pubmed/34261659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abi4822
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