Influence of the mesenchymal stromal cell source on the hematopoietic supportive capacity of umbilical cord blood-derived CD34(+)-enriched cells

BACKGROUND: Umbilical cord blood (UCB) is a clinically relevant alternative source of hematopoietic stem/progenitor cells (HSPC). To overcome the low cell number per UCB unit, ex vivo expansion of UCB HSPC in co-culture with mesenchymal stromal cells (MSC) has been established. Bone marrow (BM)-deri...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Bucar, Sara, Branco, André Dargen de Matos, Mata, Márcia F., Milhano, João Coutinho, Caramalho, Íris, Cabral, Joaquim M. S., Fernandes-Platzgummer, Ana, da Silva, Cláudia L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8278708/
https://ncbi.nlm.nih.gov/pubmed/34256848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02474-8
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