Influence of Ile655Val polymorphism on trastuzumab-induced cardiotoxicity in early-stage HER2 positive breast cancer

Trastuzumab has improved the prognosis of HER2 positive breast cancer, but cardiotoxicity remains a concern. We aimed to identify risk factors for trastuzumab-induced cardiotoxicity, with an emphasis on the HER2 Ile655Val single nucleotide polymorphism. This single-center case–control study included...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vazdar, Ljubica, Gabrić, Ivo Darko, Kruljac, Ivan, Pintarić, Hrvoje, Šeparović, Robert, Kirigin Biloš, Lora Stanka, Pavlović, Mirjana, Tečić Vuger, Ana, Štefanović, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8277791/
https://ncbi.nlm.nih.gov/pubmed/34257352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93634-6
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