Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumor cells. The promising preclinical and clinical efficacy of...

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Publicado en:Sci Rep
Main Authors: Haber, Lauric, Olson, Kara, Kelly, Marcus P., Crawford, Alison, DiLillo, David J., Tavaré, Richard, Ullman, Erica, Mao, Shu, Canova, Lauren, Sineshchekova, Olga, Finney, Jennifer, Pawashe, Arpita, Patel, Supriya, McKay, Ryan, Rizvi, Sahar, Damko, Ermelinda, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, D’Orvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Chen, Ya Ping, Thwaites, Courtney, Dudgeon, Drew, Bray, Kevin, Rafique, Ashique, Huang, Tammy, Delfino, Frank, Hermann, Aynur, Kirshner, Jessica R., Retter, Marc W., Babb, Robert, MacDonald, Douglas, Chen, Gang, Olson, William C., Thurston, Gavin, Davis, Samuel, Lin, John C., Smith, Eric
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8277787/
https://ncbi.nlm.nih.gov/pubmed/34257348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93842-0
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