VEGFA’s distal enhancer regulates its alternative splicing in CML

Enhancer demethylation in leukemia has been shown to lead to overexpression of genes which promote cancer characteristics. The vascular endothelial growth factor A (VEGFA) enhancer, located 157 Kb downstream of its promoter, is demethylated in chronic myeloid leukemia (CML). VEGFA has several altern...

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Bibliografske podrobnosti
izdano v:NAR Cancer
Main Authors: Dahan, Sara, Sharma, Aveksha, Cohen, Klil, Baker, Mai, Taqatqa, Nadeen, Bentata, Mercedes, Engal, Eden, Siam, Ahmad, Kay, Gillian, Drier, Yotam, Elias, Shlomo, Salton, Maayan
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
Cancer Gene Regulation, Chromatin, and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276762/
https://ncbi.nlm.nih.gov/pubmed/34316716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcab029
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