Development and Evaluation of an Ebola Virus Glycoprotein Mucin-Like Domain Replacement System as a New Dendritic Cell-Targeting Vaccine Approach against HIV-1

The development of efficient vaccine approaches against HIV infection remains challenging in the vaccine field. Here, we developed an Ebola virus envelope glycoprotein (EboGP)-based chimeric fusion protein system and demonstrated that replacement of the mucin-like domain (MLD) of EboGP with HIV C2-V...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Ao, Zhujun, Wang, Lijun, Azizi, Hiva, Olukitibi, Titus Abiola, Kobinger, Gary, Yao, Xiaojian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274623/
https://ncbi.nlm.nih.gov/pubmed/34011553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02368-20
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