Discovery and Optimization of a Series of Benzofuran Selective ERAP1 Inhibitors: Biochemical and In Silico Studies

[Image: see text] ERAP1 is a key aminopeptidase involved in peptide trimming before major histocompatibility complex (MHC) presentation. A single nucleotide polymorphism (SNP) in the ERAP1 gene can lead to impaired trimming activity and affect ERAP1 function. ERAP1 genetic variations have been linke...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Deddouche-Grass, Safia, Andouche, Cyrielle, Bärenz, Felix, Halter, Célia, Hohwald, Arnaud, Lebrun, Louison, Membré, Nathalie, Morales, Renaud, Muzet, Nicolas, Poirot, Matthieu, Reynaud, Morgane, Roujean, Véronique, Weber, Fabienne, Zimmermann, André, Heng, Rama, Basse, Nicolas
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2021
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274102/
https://ncbi.nlm.nih.gov/pubmed/34267884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00235
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