Fine-mapping, trans-ancestral, and genomic analyses identify causal variants, cells, genes, and drug targets for type 1 diabetes

We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 78 genome-wide significant (P < 5 × 10(−8)) regions, including 36 novel. We define credible sets of T1D-associated variants and show they are enriched in immune cell-accessible ch...

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Publicado no:Nat Genet
Main Authors: Robertson, Catherine C., Inshaw, Jamie R. J., Onengut-Gumuscu, Suna, Chen, Wei-Min, Santa Cruz, David Flores, Yang, Hanzhi, Cutler, Antony J., Crouch, Daniel J. M., Farber, Emily, Bridges, S. Louis, Edberg, Jeffrey C., Kimberly, Robert P., Buckner, Jane H., Deloukas, Panos, Divers, Jasmin, Dabelea, Dana, Lawrence, Jean M., Marcovina, Santica, Shah, Amy S., Greenbaum, Carla J., Atkinson, Mark A., Gregersen, Peter K., Oksenberg, Jorge R., Pociot, Flemming, Rewers, Marian J., Steck, Andrea K., Dunger, David B., Wicker, Linda S., Concannon, Patrick, Todd, John A., Rich, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273124/
https://ncbi.nlm.nih.gov/pubmed/34127860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00880-5
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