In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) is a promising target for antiviral drugs. In this study, a chemical library (n = 300) was screened against the nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain. Blind docking was perf...

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Detalhes bibliográficos
Publicado no:Chem Phys Lett
Main Authors: Pitsillou, Eleni, Liang, Julia, Yu Meng Huang, Helen, Hung, Andrew, Karagiannis, Tom C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273049/
https://ncbi.nlm.nih.gov/pubmed/34305155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cplett.2021.138889
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