Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes

Demyelination is a key pathogenic feature of multiple sclerosis (MS). Here, we evaluated the astrocyte contribution to myelin loss and focused on the neurotrophin receptor TrkB, whose up-regulation on the astrocyte finely demarcated chronic demyelinated areas in MS and was paralleled by neurotrophin...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Colombo, Emanuela, Triolo, Daniela, Bassani, Claudia, Bedogni, Francesco, Di Dario, Marco, Dina, Giorgia, Fredrickx, Evelien, Fermo, Isabella, Martinelli, Vittorio, Newcombe, Jia, Taveggia, Carla, Quattrini, Angelo, Comi, Giancarlo, Farina, Cinthia
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8271600/
https://ncbi.nlm.nih.gov/pubmed/34183414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025804118
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