Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors

Loss of nuclear SMARCB1 (INI1/hSNF5/BAF47) protein expression due to biallelic mutations of the SMARCB1 tumor suppressor gene is a hallmark of atypical teratoid/rhabdoid tumors (ATRT), but the presence of cytoplasmic SMARCB1 protein in these tumors has not yet been described. In a series of 102 prim...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Acta Neuropathol
Autori principali: Pathak, Rajiv, Zin, Francesca, Thomas, Christian, Bens, Susanne, Gayden, Tenzin, Karamchandani, Jason, Dudley, Roy W., Nemes, Karolina, Johann, Pascal D., Oyen, Florian, Kordes, Uwe, Jabado, Nada, Siebert, Reiner, Paulus, Werner, Kool, Marcel, Frühwald, Michael C., Albrecht, Steffen, Kalpana, Ganjam V., Hasselblatt, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2021
Soggetti:
Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270878/
https://ncbi.nlm.nih.gov/pubmed/34003336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-021-02328-w
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi