Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway

The response of endothelial cells to mechanical forces is a critical determinant of vascular health. Vascular pathologies, such as atherosclerosis, characterized by abnormal mechanical forces are frequently accompanied by endothelial-to-mesenchymal transition (EndMT). However, how forces affect the...

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Dettagli Bibliografici
Pubblicato in:Sci Adv
Autori principali: Mehta, Vedanta, Pang, Kar-Lai, Givens, Christopher S., Chen, Zhongming, Huang, Jianhua, Sweet, Daniel T., Jo, Hanjoong, Reader, John S., Tzima, Ellie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2021
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270486/
https://ncbi.nlm.nih.gov/pubmed/34244146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg5060
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