The Role of Hypoxic Bone Marrow Microenvironment in Acute Myeloid Leukemia and Future Therapeutic Opportunities

Acute myeloid leukemia (AML) is a hematologic malignancy caused by a wide range of alterations responsible for a high grade of heterogeneity among patients. Several studies have demonstrated that the hypoxic bone marrow microenvironment (BMM) plays a crucial role in AML pathogenesis and therapy resp...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Bruno, Samantha, Mancini, Manuela, De Santis, Sara, Monaldi, Cecilia, Cavo, Michele, Soverini, Simona
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269413/
https://ncbi.nlm.nih.gov/pubmed/34202238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136857
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