High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

BACKGROUND: High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by extensive inter- and intratumour heterogeneity, resulting in persistent therapeutic resistance and poor disease outcome. Molecular subtype classification based on bulk RNA sequencing facilitates a more accurate characteri...

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Veröffentlicht in:Genome Med
Hauptverfasser: Olbrecht, Siel, Busschaert, Pieter, Qian, Junbin, Vanderstichele, Adriaan, Loverix, Liselore, Van Gorp, Toon, Van Nieuwenhuysen, Els, Han, Sileny, Van den Broeck, Annick, Coosemans, An, Van Rompuy, Anne-Sophie, Lambrechts, Diether, Vergote, Ignace
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268616/
https://ncbi.nlm.nih.gov/pubmed/34238352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-021-00922-x
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