Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells

BACKGROUND: Naïve and primed pluripotent stem cells (PSCs) represent two different pluripotent states. Primed PSCs following in vitro culture exhibit lower developmental potency as evidenced by failure in germline chimera assays, unlike mouse naïve PSCs. However, the molecular mechanisms underlying...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Fu, Haifeng, Zhang, Weiyu, Li, Niannian, Yang, Jiao, Ye, Xiaoying, Tian, Chenglei, Lu, Xinyi, Liu, Lin
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268579/
https://ncbi.nlm.nih.gov/pubmed/34243810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02417-9
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