Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi

Hydroxymethylnitrofurazone (NFOH) is a therapeutic candidate for Chagas disease (CD). It has negligible hepatotoxicity in a murine model compared to the front-line drug benznidazole (BZN). Here, using Trypanosoma cruzi strains that express bioluminescent and/or fluorescent reporter proteins, we furt...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Scarim, Cauê Benito, Olmo, Francisco, Ferreira, Elizabeth Igne, Chin, Chung Man, Kelly, John M., Fortes Francisco, Amanda
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268475/
https://ncbi.nlm.nih.gov/pubmed/34203228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136930
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