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Iron Chelator Induces Apoptosis in Osteosarcoma Cells by Disrupting Intracellular Iron Homeostasis and Activating the MAPK Pathway

Osteosarcoma is a common malignant bone tumor in clinical orthopedics. Iron chelators have inhibitory effects on many cancers, but their effects and mechanisms in osteosarcoma are still uncertain. Our in vitro results show that deferoxamine (DFO) and deferasirox (DFX), two iron chelators, significan...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Xue, Yanru, Zhang, Gejing, Zhou, Shoujie, Wang, Shenghang, Lv, Huanhuan, Zhou, Liangfu, Shang, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268062/
https://ncbi.nlm.nih.gov/pubmed/34281233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22137168
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