The Lrat(−/−) Rat: CRISPR/Cas9 Construction and Phenotyping of a New Animal Model for Retinitis Pigmentosa

Purpose: We developed and phenotyped a pigmented knockout rat model for lecithin retinol acyltransferase (LRAT) using CRISPR/Cas9. The introduced mutation (c.12delA) is based on a patient group harboring a homologous homozygous frameshift mutation in the LRAT gene (c.12delC), causing a dysfunctional...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Koster, Céline, van den Hurk, Koen T., Lewallen, Colby F., Talib, Mays, ten Brink, Jacoline B., Boon, Camiel J. F., Bergen, Arthur A.
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267968/
https://ncbi.nlm.nih.gov/pubmed/34281288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22137234
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