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Zn-Enhanced Asp-Rich Antimicrobial Peptides: N-Terminal Coordination by Zn(II) and Cu(II), Which Distinguishes Cu(II) Binding to Different Peptides

The antimicrobial activity of surfactant-associated anionic peptides (SAAPs), which are isolated from the ovine pulmonary surfactant and are selective against the ovine pathogen Mannheimia haemolytica, is strongly enhanced in the presence of Zn(II) ions. Both calorimetry and ITC measurements show th...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Miller, Adriana, Matera-Witkiewicz, Agnieszka, Mikołajczyk, Aleksandra, Wątły, Joanna, Wilcox, Dean, Witkowska, Danuta, Rowińska-Żyrek, Magdalena
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267837/
https://ncbi.nlm.nih.gov/pubmed/34203496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136971
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