Blockage of Cholinergic Signaling via Muscarinic Acetylcholine Receptor 3 Inhibits Tumor Growth in Human Colorectal Adenocarcinoma

SIMPLE SUMMARY: Darifenacin is a selective muscarinic acetylcholine receptor 3 (M3R) antagonist in clinical use for benign bladder disorders. Here, the effects of M3R blockage by darifenacin on human colon adenocarcinoma cells are analyzed in vitro and in vivo. M3R expression was found in the majori...

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Published in:Cancers (Basel)
Main Authors: Hering, Nina A., Liu, Verena, Kim, Rayoung, Weixler, Benjamin, Droeser, Raoul A., Arndt, Marco, Pozios, Ioannis, Beyer, Katharina, Kreis, Martin E., Seeliger, Hendrik
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267754/
https://ncbi.nlm.nih.gov/pubmed/34203220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13133220
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