Development of selective protease inhibitors via engineering of the bait region of human α(2)-macroglobulin

Human α(2)-macroglobulin (A2M) is an abundant protease inhibitor in plasma, which regulates many proteolytic processes and is involved in innate immunity. A2M’s unique protease-trapping mechanism of inhibition is initiated when a protease cleaves within the exposed and highly susceptible “bait regio...

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Publicado en:J Biol Chem
Main Authors: Harwood, Seandean Lykke, Nielsen, Nadia Sukusu, Diep, Khang, Jensen, Kathrine Tejlgård, Nielsen, Peter Kresten, Yamamoto, Kazuhiro, Enghild, Jan J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267569/
https://ncbi.nlm.nih.gov/pubmed/34139236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100879
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