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In vitro selection of Giardia duodenalis for Albendazole resistance identifies a β-tubulin mutation at amino acid E198K

Benzimidazole-2-carbamate (BZ) compounds, including Albendazole (Alb), are one of just two drug classes approved to treat the gastrointestinal protist Giardia duodenalis. Benzimidazoles bind to the tubulin dimer interface overlapping the colchicine binding site (CBS) of β-tubulin, thereby inhibiting...

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Dades bibliogràfiques
Publicat a:Int J Parasitol Drugs Drug Resist
Autors principals: Emery-Corbin, Samantha J., Su, Qiao, Tichkule, Swapnil, Baker, Louise, Lacey, Ernest, Jex, Aaron R.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267433/
https://ncbi.nlm.nih.gov/pubmed/34237690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2021.05.003
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