Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway

PURPOSE: Is it possible to eliminate metastasised chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) cells from ovarian cortex fragments by inhibition of Aurora B/C kinases (AURKB/C) without compromising ovarian tissue or follicles? METHODS: Human ovarian cortex tissue with experiment...

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Vydáno v:J Assist Reprod Genet
Hlavní autoři: Eijkenboom, Lotte, Mulder, Callista, van der Reijden, Bert, van Mello, Norah, van Leersum, Julia, Koorenhof-Scheele, Thessa, Braat, Didi, Beerendonk, Catharina, Peek, Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2021
Témata:
Fertility Preservation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266964/
https://ncbi.nlm.nih.gov/pubmed/33725274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-021-02081-9
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