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DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers. However, the adverse effects including normal tissues injury are also accompanie...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Huang, Ruixue, Zhou, Ping-Kun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266832/
https://ncbi.nlm.nih.gov/pubmed/34238917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00648-7
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