High-throughput hydrogen deuterium exchange mass spectrometry (HDX-MS) coupled with subzero-temperature ultrahigh pressure liquid chromatography (UPLC) separation for complex sample analysis

Hydrogen deuterium exchange coupled with mass spectrometry (HDX-MS) is a powerful technique for the characterization of protein dynamics and protein interactions. Recent technological developments in the HDX-MS field, such as sub-zero LC separations, large-scale data analysis tools, and efficient pr...

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Pubblicato in:Anal Chim Acta
Autori principali: Fang, Mulin, Wang, Zhe, Cupp-Sutton, Kellye A., Welborn, Thomas, Smith, Kenneth, Wu, Si
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8265693/
https://ncbi.nlm.nih.gov/pubmed/33384131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aca.2020.11.022
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