Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4

We report the synthesis and photochemical and biological characterization of the first selective and potent metal-based inhibitors of cytochrome P450 3A4 (CYP3A4), the major human drug metabolizing enzyme. Five Ru(II)-based derivatives were prepared from two analogs of the CYP3A4 inhibitor ritonavir...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Toupin, Nicholas, Steinke, Sean J., Nadella, Sandeep, Li, Ao, Rohrabaugh, Thomas N., Samuels, Eric R., Turro, Claudia, Sevrioukova, Irina F., Kodanko, Jeremy J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8265689/
https://ncbi.nlm.nih.gov/pubmed/34110801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c04155
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