Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA(A) receptor positive allosteric modulator

Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid GABA(A) receptor positive allosteric modulator designed with the pharmacokinetic properties to support oral daily dosing. In vitro, zuranolone enhanced GABA(A) receptor current at nine unique human recombinant receptor s...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuropharmacology
Auteurs principaux: Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G., Hoffmann, Ethan, Hammond, Rebecca S., Robichaud, Albert J., Quirk, Michael C., Doherty, James J.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8265595/
https://ncbi.nlm.nih.gov/pubmed/32976892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2020.108333
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