Normal Numbers of Stem Cell Memory T Cells Despite Strongly Reduced Naive T Cells Support Intact Memory T Cell Compartment in Ataxia Telangiectasia

Ataxia Telangiectasia (AT) is a rare inherited disorder characterized by progressive cerebellar ataxia, chromosomal instability, cancer susceptibility and immunodeficiency. AT is caused by mutations in the ATM gene, which is involved in multiple processes linked to DNA double strand break repair. Im...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Weitering, Thomas J., Melsen, Janine E., van Ostaijen-ten Dam, Monique M., Weemaes, Corry M. R., Schilham, Marco W., van der Burg, Mirjam
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264762/
https://ncbi.nlm.nih.gov/pubmed/34248969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.686333
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