Leptin and Melanocortin Signaling Mediates Hypertension in Offspring From Female Rabbits Fed a High-Fat Diet During Gestation and Lactation

Maternal high-fat diet in rabbits leads to hypertension and elevated renal sympathetic nerve activity (RSNA) in adult offspring but whether this is due to adiposity or maternal programming is unclear. We gave intracerebroventricular (ICV) and ventromedial hypothalamus (VMH) administration of leptin-...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Lim, Kyungjoon, Burke, Sandra L., Marques, Francine Z., Jackson, Kristy L., Gueguen, Cindy, Sata, Yusuke, Armitage, James A., Head, Geoffrey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264761/
https://ncbi.nlm.nih.gov/pubmed/34248679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.693157
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