Leptin and Melanocortin Signaling Mediates Hypertension in Offspring From Female Rabbits Fed a High-Fat Diet During Gestation and Lactation

Maternal high-fat diet in rabbits leads to hypertension and elevated renal sympathetic nerve activity (RSNA) in adult offspring but whether this is due to adiposity or maternal programming is unclear. We gave intracerebroventricular (ICV) and ventromedial hypothalamus (VMH) administration of leptin-...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Lim, Kyungjoon, Burke, Sandra L., Marques, Francine Z., Jackson, Kristy L., Gueguen, Cindy, Sata, Yusuke, Armitage, James A., Head, Geoffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264761/
https://ncbi.nlm.nih.gov/pubmed/34248679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.693157
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