Deletion of Foxa1 in the mouse mammary gland results in abnormal accumulation of luminal progenitor cells: a link between reproductive factors and ER-/TNBC breast cancer?

In humans, parity without breastfeeding increases risk of estrogen receptor-negative (ER-) breast cancer and is associated with hypermethylation of FOXA1, a pioneer factor regulating lineage commitment of mammary gland luminal progenitor cells. We postulate that pregnancy-associated repression of FO...

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Bibliografiset tiedot
Julkaisussa:Am J Cancer Res
Päätekijät: Sribenja, Sirinapa, Maguire, Orla, Attwood, Kristopher, Buas, Matthew F, Palmer, Julie R, Ambrosone, Christine B, Higgins, Michael J
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: e-Century Publishing Corporation 2021
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263678/
https://ncbi.nlm.nih.gov/pubmed/34249460
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