The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding

The folding of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria is catalysed by the β-barrel assembly machinery (BAM). How lateral opening in the β-barrel of the major subunit BamA assists in OMP folding, and the contribution of membrane disruption to BAM catalysis remain unresolved...

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Udgivet i:Nat Commun
Main Authors: White, Paul, Haysom, Samuel F., Iadanza, Matthew G., Higgins, Anna J., Machin, Jonathan M., Whitehouse, James M., Horne, Jim E., Schiffrin, Bob, Carpenter-Platt, Charlotte, Calabrese, Antonio N., Storek, Kelly M., Rutherford, Steven T., Brockwell, David J., Ranson, Neil A., Radford, Sheena E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263589/
https://ncbi.nlm.nih.gov/pubmed/34234105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24432-x
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