The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells

The small GTPase RHOJ is a key regulator of breast cancer metastasis by promoting cell migration and invasion. The prometastatic stimulus TGF-β activates RHOJ transcription via megakaryocytic leukemia 1 (MKL1). The underlying epigenetic mechanism is not clear. Here, we report that MKL1 deficiency le...

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Vydáno v:Front Cell Dev Biol
Hlavní autoři: Zhang, Ziyu, Chen, Baoyu, Zhu, Yuwen, Zhang, Tianyi, Zhang, Xiaoling, Yuan, Yibiao, Xu, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262595/
https://ncbi.nlm.nih.gov/pubmed/34249916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.664375
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