Integration of spatial and single-cell transcriptomics localizes epithelial cell–immune cross-talk in kidney injury

Single-cell sequencing studies have characterized the transcriptomic signature of cell types within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional and affects cells heterogeneously. We first optimized coordination of spatial transcriptomics and single-nuclear...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Ferreira, Ricardo Melo, Sabo, Angela R., Winfree, Seth, Collins, Kimberly S., Janosevic, Danielle, Gulbronson, Connor J., Cheng, Ying-Hua, Casbon, Lauren, Barwinska, Daria, Ferkowicz, Michael J., Xuei, Xiaoling, Zhang, Chi, Dunn, Kenneth W., Kelly, Katherine J., Sutton, Timothy A., Hato, Takashi, Dagher, Pierre C., El-Achkar, Tarek M., Eadon, Michael T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
Schlagworte:
Resource and Technical Advance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262485/
https://ncbi.nlm.nih.gov/pubmed/34003797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147703
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