Integration of spatial and single-cell transcriptomics localizes epithelial cell–immune cross-talk in kidney injury

Single-cell sequencing studies have characterized the transcriptomic signature of cell types within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional and affects cells heterogeneously. We first optimized coordination of spatial transcriptomics and single-nuclear...

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Publicado en:JCI Insight
Autores principales: Ferreira, Ricardo Melo, Sabo, Angela R., Winfree, Seth, Collins, Kimberly S., Janosevic, Danielle, Gulbronson, Connor J., Cheng, Ying-Hua, Casbon, Lauren, Barwinska, Daria, Ferkowicz, Michael J., Xuei, Xiaoling, Zhang, Chi, Dunn, Kenneth W., Kelly, Katherine J., Sutton, Timothy A., Hato, Takashi, Dagher, Pierre C., El-Achkar, Tarek M., Eadon, Michael T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
Materias:
Resource and Technical Advance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262485/
https://ncbi.nlm.nih.gov/pubmed/34003797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147703
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