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Neddylation stabilizes Na(v)1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models
The excitability of interneurons requires Na(v)1.1, the α subunit of the voltage-gated sodium channel. Na(v)1.1 deficiency and mutations reduce interneuron excitability, a major pathological mechanism for epilepsy syndromes. However, the regulatory mechanisms of Na(v)1.1 expression remain unclear. H...
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| Gepubliceerd in: | J Clin Invest |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8262483/ https://ncbi.nlm.nih.gov/pubmed/33651714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136956 |
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