Neddylation stabilizes Na(v)1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models

The excitability of interneurons requires Na(v)1.1, the α subunit of the voltage-gated sodium channel. Na(v)1.1 deficiency and mutations reduce interneuron excitability, a major pathological mechanism for epilepsy syndromes. However, the regulatory mechanisms of Na(v)1.1 expression remain unclear. H...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Chen, Wenbing, Luo, Bin, Gao, Nannan, Li, Haiwen, Wang, Hongsheng, Li, Lei, Cui, Wanpeng, Zhang, Lei, Sun, Dong, Liu, Fang, Dong, Zhaoqi, Ren, Xiao, Zhang, Hongsheng, Su, Huabo, Xiong, Wen-Cheng, Mei, Lin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262483/
https://ncbi.nlm.nih.gov/pubmed/33651714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136956
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