Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation

Although cancer cells are frequently faced with a nutrient- and oxygen-poor microenvironment, elevated hexosamine-biosynthesis pathway (HBP) activity and protein O-GlcNAcylation (a nutrient sensor) contribute to rapid growth of tumor and are emerging hallmarks of cancer. Inhibiting O-GlcNAcylation c...

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Pubblicato in:J Clin Invest
Autori principali: Xiang, Jin, Chen, Chang, Liu, Rui, Gou, Dongmei, Chang, Lei, Deng, Haijun, Gao, Qingzhu, Zhang, Wanjun, Tuo, Lin, Pan, Xuanming, Liang, Li, Xia, Jie, Huang, Luyi, Yao, Ke, Wang, Bohong, Hu, Zeping, Huang, Ailong, Wang, Kai, Tang, Ni
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262473/
https://ncbi.nlm.nih.gov/pubmed/33690219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI144703
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