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MMP2 and TLRs modulate immune responses in the tumor microenvironment

The presence of an immunosuppressive tumor microenvironment is a major obstacle in the success of cancer immunotherapies. Because extracellular matrix components can shape the microenvironment, we investigated the role of matrix metalloproteinase 2 (MMP2) in melanoma tumorigenesis. We found that MMP...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Muniz-Bongers, Luciana R., McClain, Christopher B., Saxena, Mansi, Bongers, Gerold, Merad, Miriam, Bhardwaj, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262464/
https://ncbi.nlm.nih.gov/pubmed/34032639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144913
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