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Mechanical characterization of base analogue modified nucleic acids by force spectroscopy
We use mechanical unfolding of single DNA hairpins with modified bases to accurately assess intra- and intermolecular forces in nucleic acids. As expected, the modification stabilizes the hybridized hairpin, but we also observe intriguing stacking interactions in the unfolded hairpin. Our study high...
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| Publicat a: | Phys Chem Chem Phys |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Royal Society of Chemistry
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8261857/ https://ncbi.nlm.nih.gov/pubmed/34180930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cp01985f |
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