Cost effectiveness of pharmacogenetic-guided clozapine administration based on risk of HLA variants in Japan and the UK

Pharmacogenetics/pharmacogenomics have enabled the detection of risk of human leukocyte antigen (HLA) variants for clozapine-induced agranulocytosis/granulocytopenia (CIAG). To apply this evidence to the clinical setting, we compared the cost-effectiveness of the proposed “HLA-guided treatment sched...

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Veröffentlicht in:Transl Psychiatry
Hauptverfasser: Ninomiya, Kohei, Saito, Takeo, Okochi, Tomo, Taniguchi, Satoru, Shimasaki, Ayu, Aoki, Rei, Hata, Takeo, Mushiroda, Taisei, Kanazawa, Tetsufumi, Ikeda, Masashi, Iwata, Nakao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260588/
https://ncbi.nlm.nih.gov/pubmed/34230449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-021-01487-4
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