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Evolution of frustrated and stabilising contacts in reconstructed ancient proteins

Energetic properties of a protein are a major determinant of its evolutionary fitness. Using a reconstruction algorithm, dating the reconstructed proteins and calculating the interaction network between their amino acids through a coevolutionary approach, we studied how the interactions that stabili...

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Detalhes bibliográficos
Publicado no:Eur Biophys J
Main Authors: Crippa, Martina, Andreghetti, Damiano, Capelli, Riccardo, Tiana, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260555/
https://ncbi.nlm.nih.gov/pubmed/33569610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00249-021-01500-0
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